Aug 22, 2023 · Effexor XR (venlafaxine) is used to treat major depressive disorder, anxiety, and panic disorder. Includes Effexor XR side effects, interactions and indications. Dec 31, 2015 · Venlafaxine is officially approved to treat major depressive disorder (MDD), generalized anxiety disorder (GAD), social anxiety disorder, and panic disorder in adults. 17 The immediate formulation of the drug, marketed as Effexor, was first approved by the FDA in 1993 and the extended-release formulation, Effexor XR, was later introduced in ... I also suffer from Generalized Anxiety & OCD and recently started Effexor XR earlier this week, 37.5 MG. I have a chronic issue of going on a medication and quitting before getting past the "hell" stage or not starting the medication at all due to anxiety brought on by reading the side effects and others bad reactions.Mar 11, 2018 · This medication is not prescribed for weight loss. It is for anxiety and depression. If you lose weight, which varies from patient to patient, consider it a plus if you are a bit obese, otherwise concentrate of the effects of what it was intended to do. Votes: +1. TR. Improvement in these physical symptoms can be an important early signal that the medication is working. Depressed mood, anxiety, and lack of interest in activities may need up to 6-8 weeks to fully improve." Venlafaxine (Effexor) | NAMI: National Alliance on Mental Illness. +0.Aug 1, 2023 · Effexor; Effexor-XR; Descriptions. Venlafaxine is used to treat depression. It is also used to treat general anxiety disorder, social anxiety disorder, and panic disorder. Venlafaxine belongs to a group of medicines known as serotonin and norepinephrine reuptake inhibitors (SNRI). CH. chuck1957 6 April 2016. Vanilla; Really this is very common when you first start this type of medication, And the first 1 to 2 weeks is the hardest time with this mediction and it does increase the symptoms that it is made to help. Also after this time slowly these medications effects go away and you start to feel better as the time goes on.Effexor XR (venlafaxine) is used to treat major depressive disorder, anxiety, and panic disorder. Includes Effexor XR side effects, interactions and indications.Taking selective serotonin reuptake inhibitors (SNRIs), including EFFEXOR XR, may cause sexual problems. nausea. sleepiness. dry mouth. male and female sexual problems. loss of appetite (anorexia) sweating. constipation. It is not known if EFFEXOR XR is safe and effective for use in children. Effexor (venlafaxine) is considered "weight neutral" because weight changes, if there are any at all, can go either way: "Very common (10% or more of users): Anorexia (up to 20%) Common (1% to 10% of users): Decreased appetite, increased appetite, weight gain, weight loss". Note that most people do not experience any weight change.Effexor; Effexor-XR; Descriptions. Venlafaxine is used to treat depression. It is also used to treat general anxiety disorder, social anxiety disorder, and panic disorder. Venlafaxine belongs to a group of medicines known as serotonin and norepinephrine reuptake inhibitors (SNRI).Taking selective serotonin reuptake inhibitors (SNRIs), including EFFEXOR XR, may cause sexual problems. nausea. sleepiness. dry mouth. male and female sexual problems. loss of appetite (anorexia) sweating. constipation. It is not known if EFFEXOR XR is safe and effective for use in children. Effexor Weight Gain And Loss: Why It Happens. Venlafaxine is thought to be a weight-neutral drug in the medical literature. This is because it may cause some patients to gain pounds while others can lose them while being treated with Effexor. Most venlafaxine effects, including weight changes, are characteristic features of the entire SNRI class.كبسولات ايفيكسور اكس ار ( EFEXOR XR ) , امراض نفسية ينتمي العلاج إلى عائلة مثبطات استرداد السيريتونين و النورأدرنالين الانتقائية، والتي تعمل على زيادة نسبة النواقل العصبي...Improvement in these physical symptoms can be an important early signal that the medication is working. Depressed mood, anxiety, and lack of interest in activities may need up to 6-8 weeks to fully improve." Venlafaxine (Effexor) | NAMI: National Alliance on Mental Illness. +0.Sep 30, 2022 · The milder approach to mitigate long-term Effexor XR effects is the longer timeline. 7,20,21. Timing: If Effexor XR is usually taken in the morning, continue that schedule. Do not suddenly switch to taking it before bed or randomly during waking hours. Inpatient Care: Speak to your physician about inpatient care. Effexor (venlafaxine) is considered "weight neutral" because weight changes, if there are any at all, can go either way: "Very common (10% or more of users): Anorexia (up to 20%) Common (1% to 10% of users): Decreased appetite, increased appetite, weight gain, weight loss". Note that most people do not experience any weight change.Nov 18, 2021 · Effexor XR (venlafaxine hydrochloride) extended-release capsules are indicated for the treatment of major depressive disorder (MDD). Efficacy was established in three short-term (4, 8, and 12 weeks) and two long-term, maintenance trials. Generalized Anxiety Disorder. Effexor XR is indicated for the treatment of Generalized Anxiety Disorder ... EA. Earth2missy 31 Jan 2022. I have been taking Effexor XR for over 15 years and definitely have terrible side effects if I miss one dose at night. I take them at bedtime because they make me sick. If I miss it at nite by mid morning I am feeling extremely sad, teary, make bad decisions, and emotional, nauseous.1-3 days after the last dose. During the first few days of Effexor detox, mild withdrawal symptoms may start to appear. 4-5 days after the last dose. Withdrawal symptoms often become more intense several days into Effexor detox and they may include nausea, shakiness, dizziness, and insomnia, among others. 1-3 weeks after the last dose.Mechanism of Action. Venlafaxine and its active metabolite, O-desmethylvenlafaxine (ODV), are potent inhibitors of neuronal serotonin and norepinephrine reuptake and weak inhibitors of dopamine reuptake. Venlafaxine and ODV have no significant activity for muscarinic cholinergic, H 1 -histaminergic, or alpha 2 -adrenergic receptors.Loss of libido (sex drive) was a common side effect in males* and females* taking Effexor XR. Other sexual side effects in males may include: abnormal ejaculation. erectile dysfunction (inability ...Antidepressants may increase risk of suicidal thinking and behavior (suicidality) in children, adolescents, and young adults (18–24 years of age) with major depressive disorder and other psychiatric disorders; balance this risk with clinical need. Venlafaxine is not approved for use in pediatric patients. (See Pediatric Use under Cautions.)Effexor XR is indicated for the treatment of Social Anxiety Disorder (SAD), also known as social phobia. Efficacy was established in four 12-week and one 26-week, placebo-controlled trials. 1.4 Panic Disorder . Effexor XR is indicated for the treatment of Panic Disorder (PD), with or without agoraphobia. Efficacy Jan 12, 2023 · In one study, in which patients responding during 8 weeks of acute treatment with Effexor XR were assigned randomly to placebo or to the same dose of Effexor XR (75, 150, or 225 mg/day, qAM) during 26 weeks of maintenance treatment as they had received during the acute stabilization phase, longer-term efficacy was demonstrated. This Savings Offer and Program expire on 12/31/2023. For help with the EFFEXOR XR Savings Offer, call 1-855-488-0750, visit EFFEXORXR.com, or write: Viatris, P.O. Box 2941, Mission, KS 66201. If your pharmacy does not participate, you may be able to submit a request for a rebate in connection with this Savings Offer.Effexor is a tricky one but at least your switching to another SNRI. If your Dr will Rx you the instant release they make 100, 75, 50, 37.5, and 25mg tabs that can be split safely and ideally I would go 250x5, 200x5, 150x5, then 75x5 but add the 30 of Cymbalta then after 5 days I would go to the 60mg dose. Both of the others that answered are ...Oct 17, 2015 · Effexor (venlafaxine) is considered "weight neutral" because weight changes, if there are any at all, can go either way: "Very common (10% or more of users): Anorexia (up to 20%) Common (1% to 10% of users): Decreased appetite, increased appetite, weight gain, weight loss". Note that most people do not experience any weight change. Severe symptoms of Effexor withdrawal that may require immediate medical attention include: 1. Suicidal thoughts: Effexor withdrawal can increase the risk of suicidal ideation or action. Constant headaches: Effexor withdrawal can lead to continuous and persistent headaches that can grow intense over time.Effexor XR (venlafaxine hydrochloride) extended-release capsules are indicated for the treatment of major depressive disorder (MDD). Efficacy was established in three short-term (4, 8, and 12 weeks) and two long-term, maintenance trials. Generalized Anxiety Disorder. Effexor XR is indicated for the treatment of Generalized Anxiety Disorder ...My neurologist and psychiatrist both suggested Effexor since it can help with migraines and chronic pain. I was scared of the withdrawal and possible side effects and all these reviews but the headaches were so frequent I needed to do som. 1. Report this post.For Depression "I have been on effexor xr for about 8 years now, I currently am taking 300 mg per day, I tried to commit suicide several times before going on effexor, I had been on so many different antidepressants I thought this was how my life was always going to be my children slowly watching me sleep and then eventually die. The doctor put ...Improvement in these physical symptoms can be an important early signal that the medication is working. Depressed mood, anxiety, and lack of interest in activities may need up to 6-8 weeks to fully improve." Venlafaxine (Effexor) | NAMI: National Alliance on Mental Illness. +0.Effexor XR is indicated for the treatment of Social Anxiety Disorder (SAD), also known as social phobia. Efficacy was established in four 12-week and one 26-week, placebo-controlled trials. 1.4 Panic Disorder Effexor XR is indicated for the treatment of Panic Disorder (PD), with or without agoraphobia. Efficacy My neurologist and psychiatrist both suggested Effexor since it can help with migraines and chronic pain. I was scared of the withdrawal and possible side effects and all these reviews but the headaches were so frequent I needed to do som. 1. Report this post.Aug 1, 2023 · Effexor; Effexor-XR; Descriptions. Venlafaxine is used to treat depression. It is also used to treat general anxiety disorder, social anxiety disorder, and panic disorder. Venlafaxine belongs to a group of medicines known as serotonin and norepinephrine reuptake inhibitors (SNRI). Tell all of your health care providers and lab workers that you take Effexor XR (venlafaxine extended-release capsules). You may see parts of Effexor XR (venlafaxine extended-release capsules) in your stool. This is normal and not a cause for concern. If you are 65 or older, use Effexor XR (venlafaxine extended-release capsules) with care.Jan 18, 2010 · EA. Earth2missy 31 Jan 2022. I have been taking Effexor XR for over 15 years and definitely have terrible side effects if I miss one dose at night. I take them at bedtime because they make me sick. If I miss it at nite by mid morning I am feeling extremely sad, teary, make bad decisions, and emotional, nauseous. Mechanism of Action. Venlafaxine and its active metabolite, O-desmethylvenlafaxine (ODV), are potent inhibitors of neuronal serotonin and norepinephrine reuptake and weak inhibitors of dopamine reuptake. Venlafaxine and ODV have no significant activity for muscarinic cholinergic, H 1 -histaminergic, or alpha 2 -adrenergic receptors.EFFEXOR XR may cause serious side effects, including: Increased risk of suicidal thoughts and actions: EFFEXOR XR may increase suicidal thoughts and actions in some children, adolescents, and young adults, especially within the first few months of treatment or when the dose is changed.Mechanism of Action. Venlafaxine and its active metabolite, O-desmethylvenlafaxine (ODV), are potent inhibitors of neuronal serotonin and norepinephrine reuptake and weak inhibitors of dopamine reuptake. Venlafaxine and ODV have no significant activity for muscarinic cholinergic, H 1 -histaminergic, or alpha 2 -adrenergic receptors.Effexor XR Brand Names: Canada ACT Venlafaxine XR; APO-Venlafaxine XR; Auro-Venlafaxine XR; Effexor XR; M-Venlafaxine XR; PMS-Venlafaxine XR; PMSC-Venlafaxine XR; RIVA-Venlafaxine XR [DSC]; SANDOZ Venlafaxine XR; TARO-Venlafaxine XR; TEVA-Venlafaxine XR; Venlafaxine XR Warning Drugs like this one have raised the chance of suicidal thoughts or Effexor XR (venlafaxine) is a prescription drug that’s used to treat depression and anxiety. The drug comes as a capsule that you swallow. It’s usually taken once per day. Effexor XR is used in...Feb 17, 2020 · Mechanism of Action. Venlafaxine and its active metabolite, O-desmethylvenlafaxine (ODV), are potent inhibitors of neuronal serotonin and norepinephrine reuptake and weak inhibitors of dopamine reuptake. Venlafaxine and ODV have no significant activity for muscarinic cholinergic, H 1 -histaminergic, or alpha 2 -adrenergic receptors. Effexor XR can cause side effects that range from mild to serious. Examples include weight changes, sweating, and high blood pressure. Effexor XR is used in adults to treat: major depressive ...May 22, 2019 · Effexor XR, the more popularly prescribed type of Effexor, is covered by most insurance and Medicare prescription plans. The generic version will have a lower copay, and the brand name may have a higher copay or may not be covered. May 22, 2019 · Effexor XR, the more popularly prescribed type of Effexor, is covered by most insurance and Medicare prescription plans. The generic version will have a lower copay, and the brand name may have a higher copay or may not be covered. Antidepressants may increase risk of suicidal thinking and behavior (suicidality) in children, adolescents, and young adults (18–24 years of age) with major depressive disorder and other psychiatric disorders; balance this risk with clinical need. Venlafaxine is not approved for use in pediatric patients. (See Pediatric Use under Cautions.)Aug 31, 2018 · Anxiety. Bipolar depression. Chronic muscle or joint pain. Diabetic neuropathy. Fibromyalgia. Low back pain or osteoarthritis pain. Panic disorder. Social phobia. Some reduction in symptoms may be noticed within one to two weeks; however, it may take six to eight weeks of treatment before the full effects are seen. Effexor XR, the more popularly prescribed type of Effexor, is covered by most insurance and Medicare prescription plans. The generic version will have a lower copay, and the brand name may have a higher copay or may not be covered.In one study, in which patients responding during 8 weeks of acute treatment with Effexor XR were assigned randomly to placebo or to the same dose of Effexor XR (75, 150, or 225 mg/day, qAM) during 26 weeks of maintenance treatment as they had received during the acute stabilization phase, longer-term efficacy was demonstrated.Effexor XR has an average rating of 6.8 out of 10 from a total of 110 reviews for the treatment of Generalized Anxiety Disorder. 57% of reviewers reported a positive experience, while 24% reported a negative experience. Filter by condition. Effexor is an antidepressant that may cause a discontinuation syndrome if abruptly stopped after long-term administration. 5. Tips. Take Effexor with food. Swallow Effexor XR capsules whole; do not break, crush, chew or attempt to dissolve in water.CH. chuck1957 6 April 2016. Vanilla; Really this is very common when you first start this type of medication, And the first 1 to 2 weeks is the hardest time with this mediction and it does increase the symptoms that it is made to help. Also after this time slowly these medications effects go away and you start to feel better as the time goes on.Two 6-month studies, one evaluating Effexor XR doses of 37.5, 75, and 150 mg per day (study 3) and the other evaluating Effexor XR doses of 75 to 225 mg per day (study 4), showed that daily doses of 75 mg or higher were more effective than placebo on the HAM-A total, both the HAM-A anxiety and tension items, and the CGI scale during 6 months of ...Effexor XR (venlafaxine hydrochloride) extended-release capsules are indicated for the treatment of major depressive disorder (MDD). Efficacy was established in three short-term (4, 8, and 12 weeks) and two long-term, maintenance trials. Generalized Anxiety Disorder. Effexor XR is indicated for the treatment of Generalized Anxiety Disorder ...Effexor XR (venlafaxine hydrochloride) extended-release capsules treatment for up to 12 weeks in premarketing placebo-controlled trials for major depressive disorder was associated with a mean final on-therapy increase in serum cholesterol concentration of approximately 1.5 mg/dL compared with a mean final decrease of 7.4 mg/dL for placebo.Jul 19, 2021 · Loss of libido (sex drive) was a common side effect in males* and females* taking Effexor XR. Other sexual side effects in males may include: abnormal ejaculation. erectile dysfunction (inability ... Two 6-month studies, one evaluating Effexor XR doses of 37.5, 75, and 150 mg per day (study 3) and the other evaluating Effexor XR doses of 75 to 225 mg per day (study 4), showed that daily doses of 75 mg or higher were more effective than placebo on the HAM-A total, both the HAM-A anxiety and tension items, and the CGI scale during 6 months of ...What Is Venlafaxine (Effexor, Effexor XR) and How Does It Work? Venlafaxine is used to treat depression, anxiety, panic attacks, and social anxiety disorder ( social phobia ). It may improve your mood and energy level and may help restore your interest in daily living. Effexor, also known as venlafaxine, is an antidepressant medication. ... Under the name Effexor, it is only available as the XR version. Generic versions are available in both immediate release ...Sertraline (Zoloft), paroxetine (Paxil), and venlafaxine ER (Effexor XR) are FDA-approved medications for social anxiety disorder. Non-medication treatments, such as cognitive behavioral therapy (CBT) and support groups, may be helpful in relieving anxiety symptoms. Ivan Pantic/E+ via Getty Images.1-3 days after the last dose. During the first few days of Effexor detox, mild withdrawal symptoms may start to appear. 4-5 days after the last dose. Withdrawal symptoms often become more intense several days into Effexor detox and they may include nausea, shakiness, dizziness, and insomnia, among others. 1-3 weeks after the last dose.EFFEXOR XR (venlafaxine extended-release) capsules are a prescription medicine used to treat adults with a certain type of depression called Major Depressive Disorder (MDD), Generalized Anxiety Disorder (GAD), Social Anxiety Disorder (SAD), or Panic Disorder (PD). It is not known if EFFEXOR XR is safe and effective for use in children.Lexapro (escitalopram) and Effexor (venlafaxine) are antidepressants used for treatment of major depression. Lexapro is also used to treat anxiety in adults. Lexapro belongs to the drug class selective serotonin reuptake inhibitors (SSRIs) while Effexor is a selective serotonin and norepinephrine reuptake inhibitor (SSNRI). Learn about dosage and side effects. Apr 24, 2023 · Tell all of your health care providers and lab workers that you take Effexor XR (venlafaxine extended-release capsules). You may see parts of Effexor XR (venlafaxine extended-release capsules) in your stool. This is normal and not a cause for concern. If you are 65 or older, use Effexor XR (venlafaxine extended-release capsules) with care. Jul 11, 2023 · Effexor XR may cause serious side effects. Call your doctor at once if you have: blurred vision, eye pain or redness, seeing halos around lights; Two 6-month studies, one evaluating Effexor XR doses of 37.5, 75, and 150 mg per day (study 3) and the other evaluating Effexor XR doses of 75 to 225 mg per day (study 4), showed that daily doses of 75 mg or higher were more effective than placebo on the HAM-A total, both the HAM-A anxiety and tension items, and the CGI scale during 6 months of ...Venlafaxine oral tablet is a prescription drug used to treat depression and social anxiety disorder (SAD). It comes in two forms: immediate-release (treats depression) and extended-release (treats ...Worked well for depression but caused me to gain lots of weight. Eventually stopped working. Takes forever to gets off. Even while weaning down by 1/4 every 2 weeks, lots of nausea, diarrhea, brain zaps, tears, headaches, sleep disturbances, and general major physical discomfort. Am on 37.5 now (last taper) and honestly just hate it so much, my ...Venlafaxine is used to treat depression. Venlafaxine extended-release (long-acting) capsules are also used to treat generalized anxiety disorder (GAD; excessive worrying that is difficult to control), social anxiety disorder (extreme fear of interacting with others or performing in front of others that interferes with normal life), and panic disorder (sudden, unexpected attacks of extreme fear ... Taking selective serotonin reuptake inhibitors (SNRIs), including EFFEXOR XR, may cause sexual problems. nausea. sleepiness. dry mouth. male and female sexual problems. loss of appetite (anorexia) sweating. constipation. It is not known if EFFEXOR XR is safe and effective for use in children.May 7, 2021 · Pristiq and Effexor are two popular medications indicated for the treatment of depression, a common mental health condition. Effexor XR (extended-release) also treats generalized anxiety disorder, panic disorder, and social anxiety. Both drugs are approved by the United States Food and Drug Administration (FDA). I also suffer from Generalized Anxiety & OCD and recently started Effexor XR earlier this week, 37.5 MG. I have a chronic issue of going on a medication and quitting before getting past the "hell" stage or not starting the medication at all due to anxiety brought on by reading the side effects and others bad reactions.Jan 5, 2012 · I started taking effexor xr 150mg in the year 2000. It's now Sept, 2016 and am on the same meds and recently was elevated to 225 mg. I suffer from depression, and have been diagnosed as having bi polar disorder. I now am getting severe "brain zaps" every day, migraines and severe dizzy spells. Effexor XR is indicated for the treatment of Social Anxiety Disorder (SAD), also known as social phobia. Efficacy was established in four 12-week and one 26-week, placebo-controlled trials. 1.4 Panic Disorder . Effexor XR is indicated for the treatment of Panic Disorder (PD), with or without agoraphobia. EfficacyAug 1, 2023 · For oral dosage forms (extended-release capsules, extended-release tablets): For depression: Adults—At first, 75 milligrams (mg) per day, taken as one dose in the morning or evening. Some patients may need a starting dose of 37.5 mg per day, taken for 4 to 7 days. Your doctor may adjust your dose as needed and tolerated. May 22, 2019 · Effexor XR, the more popularly prescribed type of Effexor, is covered by most insurance and Medicare prescription plans. The generic version will have a lower copay, and the brand name may have a higher copay or may not be covered.
Antidepressants may increase risk of suicidal thinking and behavior (suicidality) in children, adolescents, and young adults (18–24 years of age) with major depressive disorder and other psychiatric disorders; balance this risk with clinical need. Venlafaxine is not approved for use in pediatric patients. (See Pediatric Use under Cautions.). Botw traveler
Jan 5, 2012 · I started taking effexor xr 150mg in the year 2000. It's now Sept, 2016 and am on the same meds and recently was elevated to 225 mg. I suffer from depression, and have been diagnosed as having bi polar disorder. I now am getting severe "brain zaps" every day, migraines and severe dizzy spells. Weaning off Venlafaxine XR 75mg (Effexor-(extended release)capsules: Weaning plan off plan that worked for BSS: 1. Inform your doctor you are tapering down from 75 mg Venlafaxine and ask them to prescribe 37.50 tabs to help with tapering doses (1/2 dosage down from 75 mg Venlafaxine capsules).Effexor is an antidepressant that may cause a discontinuation syndrome if abruptly stopped after long-term administration. 5. Tips. Take Effexor with food. Swallow Effexor XR capsules whole; do not break, crush, chew or attempt to dissolve in water.Effexor is an antidepressant that may cause a discontinuation syndrome if abruptly stopped after long-term administration. 5. Tips. Take Effexor with food. Swallow Effexor XR capsules whole; do not break, crush, chew or attempt to dissolve in water.Effexor XR, the more popularly prescribed type of Effexor, is covered by most insurance and Medicare prescription plans. The generic version will have a lower copay, and the brand name may have a higher copay or may not be covered.Instead, Effexor is currently available in extended-release form under the brand name Effexor XR. Effexor is also available in generic form as venlafaxine. This version of the medication is sold in several forms under a variety of brand names. Generic venlafaxine and Effexor XR are prescribed to treat major depressive disorder (MDD, or ...Venlafaxine is also known as: Effexor, Effexor XR. Pregnancy Warnings; Breastfeeding Warnings; Venlafaxine Pregnancy Warnings. Animal studies have revealed increased perinatal toxicity and fetotoxicity at doses potentially correlated with maternal toxicity. There are no controlled data in human pregnancy.Venlafaxine is used to treat depression. Venlafaxine extended-release (long-acting) capsules are also used to treat generalized anxiety disorder (GAD; excessive worrying that is difficult to control), social anxiety disorder (extreme fear of interacting with others or performing in front of others that interferes with normal life), and panic disorder (sudden, unexpected attacks of extreme fear ... EFFEXOR XR may cause serious side effects, including: Increased risk of suicidal thoughts and actions. EFFEXOR XR and other antidepressant medicines may increase suicidal thoughts and actions in some children, adolescents, and young adults, especially within the first few months of treatment or when the dose is changed. EFFEXOR XR is not for ...Effexor XR (venlafaxine) is used to treat major depressive disorder, anxiety, and panic disorder. Includes Effexor XR side effects, interactions and indications.Effexor XR is indicated for the treatment of Social Anxiety Disorder (SAD), also known as social phobia. Efficacy was established in four 12-week and one 26-week, placebo-controlled trials. 1.4 Panic Disorder . Effexor XR is indicated for the treatment of Panic Disorder (PD), with or without agoraphobia. Efficacy Venlafaxine is also known as: Effexor, Effexor XR. Pregnancy Warnings; Breastfeeding Warnings; Venlafaxine Pregnancy Warnings. Animal studies have revealed increased perinatal toxicity and fetotoxicity at doses potentially correlated with maternal toxicity. There are no controlled data in human pregnancy.Feb 17, 2020 · Mechanism of Action. Venlafaxine and its active metabolite, O-desmethylvenlafaxine (ODV), are potent inhibitors of neuronal serotonin and norepinephrine reuptake and weak inhibitors of dopamine reuptake. Venlafaxine and ODV have no significant activity for muscarinic cholinergic, H 1 -histaminergic, or alpha 2 -adrenergic receptors. .